Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction
نویسندگان
چکیده
منابع مشابه
Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction
A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid...
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A facile and efficient one-pot three-step process for the synthesis of 5-acetyl-2-imino-4-methylthiazoles via the cyclocondensation of 3-thiocyanatoacetylacetone with various hydrazine or hydrazide derivatives in EtOH has been developed. 3-Thiocyanatoacetylacetone itself has been synthesized as the intermediate from substitution reaction of thiocyanate with 3-chloroacetylacetone. B...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2017
ISSN: 1860-5397
DOI: 10.3762/bjoc.13.26